Associate Scientist II
Company: Aditi Consulting
Location: Lexington
Posted on: June 24, 2025
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Job Description:
Payrate: $44.72 - $44.72/hr. Summary: The company is seeking a
highly motivated Associate Scientist II to join the Oligonucleotide
Chemistry Team. The candidate will be responsible for analysis and
purification of oligonucleotides. This position will support
therapeutic programs in multiple disease areas and will contribute
to the development of novel nucleic acid conjugate platforms. Prior
experience in LCMS method development and oligonucleotide
purification and characterization is desired. This position reports
to the Director, Oligonucleotide Chemistry as an individual
contributor. Daily interaction with other peers in oligo synthesis,
medicinal chemistry and biology teams in support of early phase
product pipeline. Responsibilities: Primary responsibility to
provide analytical lab support for Company’s Oligonucleotide early
phase pipeline Development of robust LC/MS, IPRP and SAX analytical
methods for analysis and purification of highly modified
oligonucleotide drug substances. Prepare analytical samples,
analyze and process data, primarily by UPLC, LC-MS Operate,
maintain and troubleshoot lab instruments Conduct and help design
unique experiments to help in characterization of highly modified
oligonucleotides and sgRNA Keep accurate records of the experiments
and summarize the results in well communicated presentations or
written reports Purification, deprotection, annealing and
lyophilization of oligonucleotides to support all disease programs
Oligonucleotide synthesis Possess excellent written and verbal
communication skills Conduct laboratory work in an efficient manner
that ensures a safe working environment Qualifications: MS or BS
with 3 years of industrial experience Strong knowledge of mass
spectrometry and purification techniques Experience with waters
LC/MS instruments preferred Experience with purification and LC/MS
analysis of sgRNA highly preferred Experience with analytical
techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation
Strong background in the analytical development of methods for the
analysis of oligonucleotide therapeutics Experience with
IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent,
Waters and/or Thermo UHPLC’s and associated software In depth
knowledge of GLP/GMP’s in a pharmaceutical environment The
successful candidate must possess excellent writing and
communication skills and a demonstrated ability to work
independently and with cross-functional teams Desired Skills: LC/MS
experience /oligo method development Mass Spec Maintenance and
trouble shooting Oligonucleotide Purification Pay Transparency: The
typical base pay for this role across the U.S. is: $44.72 - $44.72
/hr. Final offer amounts, within the base pay set forth above, are
determined by factors including your relevant skills, education and
experience and the benefits package you select. Full-time employees
are eligible to select from different benefits packages. Packages
may include medical, dental, and vision benefits, 10 paid days off,
401(k) plan participation, commuter benefits and life and
disability insurance. For information about our collection, use,
and disclosure of applicant's personal information as well as
applicants' rights over their personal information, please see our
Privacy Policy (https://www.aditiconsulting.com/privacy-policy).
Aditi Consulting LLC uses AI technology to engage candidates during
the sourcing process. AI technology is used to gather data only and
does not replace human-based decision making in employment
decisions. By applying for this position, you agree to Aditi’s use
of AI technology, including calls from an AI Voice Recruiter.
Keywords: Aditi Consulting, Nantucket , Associate Scientist II, Science, Research & Development , Lexington, Massachusetts
